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Using the wrong solvent or handling poorly can lead to cloudiness, precipitation, aggregation, or loss of potency

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N-hydroxy-2-acetylaminofluorene (N-OH-2-AAF) works as another proximate or ultimate after getting activated out of 2-AAF and works via alkylation of DNA (C8 of guanine)

Elmasry K, Ibrahim AS, Saleh H, Elsherbiny N, Elshafey S, Hussein KA, Al-Shabrawey M

However, when we measure the boiling points for these compounds, we find that they are dramatically higher than the trends would predict, as shown in Figure 2